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Respirology
The science of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mutations with a focus on F508del in cystic fibrosis – Certificate of Completion
Durée
Profession
Specialist
# des crédits
1.5
Accréditation
Certificate of Completion
Date d'expiration
2019-03-03
Objectifs d'apprentissage
On completion of this program, participants will be better able to:
- Recognise the classification of CFTR mutations (‘theratypes’) and potential impact on the severity of disease (‘classical’ vs ‘milder’)
- Define determinants of total CFTR activity
- Describe the F508del mutation and its pathobiology, including tissue-specific differences
- Recognise the impact of the F508del mutation on total CFTR activity
- Discuss the challenges for correction of the F508del CFTR mutation