Men who are overweight or obese are more likely to have low serum testosterone concentrations. Both of these clinical features are associated with increased risk of type 2 diabetes. In these men, a bidirectional model is proposed where diabesity may accelerate age-related decline in testosterone, associated with increased adipose mass and decreased lean mass. Dysglycaemia in turn, suppresses the HPT axis, reducing testosterone levels.
This program is supported by an independent educational grant provided from Besins.