{"id":548857,"date":"2026-03-25T10:00:00","date_gmt":"2026-03-25T14:00:00","guid":{"rendered":"https:\/\/www.mdbriefcase.com\/postcall-item\/%f0%9f%a9%ba-the-brains-built-in-kill-switch-2\/"},"modified":"2026-03-25T10:00:00","modified_gmt":"2026-03-25T14:00:00","slug":"%f0%9f%a9%ba-the-brains-built-in-kill-switch-2","status":"publish","type":"postcall","link":"https:\/\/www.mdbriefcase.com\/fr\/postcall-item\/%f0%9f%a9%ba-the-brains-built-in-kill-switch-2\/","title":{"rendered":"\ud83e\ude7a The brain’s built-in kill switch"},"content":{"rendered":"

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\ud83e\ude7a The brain's built-in kill switch<\/h1>\n

PLUS: the ADHD-mental health link, oil slows AI, and Ontario's EMR mission<\/h2>\n
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March 25, 2026 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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Good morning!<\/b><\/p>\n<\/div>\n
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If dreary, early spring days have you down, consider a sunlight lamp, or maybe moving to Finland. 2026's World Happiness Report<\/a> has been released, and Canada has slipped to 25th. Nordic countries once again top the list and Costa Rica has climbed into the top 5. The common thread isn\u2019t wealth \u2014\u00a0it's connection: strong social ties, trust in others, and the sense that someone has your back. Across countries, people who feel supported consistently rate their lives higher. Happiness, it turns out, may be less about what you have, and more about whether you\u2019re alone with it. <\/p>\n<\/div>\n
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Today\u2019s issue takes 5 minutes to read<\/span>. Only got one? Here\u2019s what to know: <\/p>\n<\/div>\n
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Blocking brain \u201cdeath switch\u201d slows Alzheimer\u2019s in mice <\/p>\n<\/li>\n
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Oil surge threatens AI growth and global trade <\/p>\n<\/li>\n
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Ontario restarts EMR push after costly failures <\/p>\n<\/li>\n
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Black Canadians face persistent prescription cost barriers <\/p>\n<\/li>\n
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Muscle strength predicts survival beyond activity levels <\/p>\n<\/li>\n<\/ul>\n<\/div>\n
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Let\u2019s get into it. <\/p>\n<\/div>\n
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Staying #Up2Date <\/span>\ud83d\udea8<\/h1>\n<\/div>\n<\/div>\n
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1: A New Player in Early Parkinson\u2019s Treatment?<\/b><\/p>\n<\/div>\n
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A Phase 3 RCT<\/a> found that oral tavapadon can safely improve motor function in patients with early Parkinson\u2019s disease. Both 5 mg and 15 mg doses of the selective D1\/D5 agonist showed significant improvement in MDS-UPDRS scores after 26 weeks compared to placebo. Adverse events were limited to nausea, headache, and dizziness, suggesting tavapadon may be a promising option in early PD therapy. <\/p>\n<\/div>\n
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2: Muscle Strength as a Marker of Longevity<\/b><\/p>\n<\/div>\n
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A cohort study<\/a> examined associations between muscular strength and mortality in over 5,400 women aged 63 to 99 years. Stronger dominant hand grip strength and faster completion of 5 unassisted chair stands were linked with lower mortality, even among those not meeting guideline-recommended activity levels. These findings remained consistent after adjusting for age, lifestyle, and clinical factors, highlighting the role of strength in healthy aging. <\/p>\n<\/div>\n
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3: Quieting Tinnitus 1 Click at a Time<\/b><\/p>\n<\/div>\n
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Follow-up of a non-randomized clinical trial<\/a> evaluating guided online cognitive behavioural therapy for tinnitus examined the long-term effects of the intervention. In 49 individuals, internet-based CBT reduced tinnitus distress over a 6-year follow-up period and improved anxiety, depression, insomnia, and life satisfaction. These findings suggest this approach may offer sustained symptom relief while reducing the resources required to deliver care. <\/p>\n<\/div>\n<\/div>\n
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Course of the Week <\/span>\ud83d\udca1<\/h1>\n<\/div>\n<\/div>\n
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A Holistic Approach to Atopic Dermatitis in Diverse Populations<\/b><\/a><\/p>\n<\/div>\n
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When a patient\u2019s atopic dermatitis (AD) isn't clearing up, it\u2019s easy to assume the prescription isn't strong enough \u2014 but often, the real culprit is a broken skin barrier. Since AD affects up to 10% of adults (with higher severity in skin of colour), a one-size-fits-all approach usually misses the mark. <\/p>\n<\/div>\n
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In this quick 15-minute course, experts like Dr. Sandy Skotnicki and Dr. Naomi Pliamm break down how to bridge the gap between pharmacotherapy and daily skincare. It\u2019s a case-based look at using ceramide-containing formulations to actually repair the foundation, helping you give better, more practical advice to your diverse patient panel. <\/p>\n<\/div>\n