{"id":2488,"date":"2023-07-25T00:00:00","date_gmt":"2023-07-25T05:00:00","guid":{"rendered":"https:\/\/mdbc2.wpenginepowered.com\/blog\/spotting-impetigo-differential-diagnosis-key-clinical-clues-and-evidence-based-treatment-approaches\/"},"modified":"2025-04-17T10:02:51","modified_gmt":"2025-04-17T15:02:51","slug":"spotting-impetigo-differential-diagnosis-key-clinical-clues-and-evidence-based-treatment-approaches","status":"publish","type":"blog","link":"https:\/\/www.mdbriefcase.com\/fr\/blog\/spotting-impetigo-differential-diagnosis-key-clinical-clues-and-evidence-based-treatment-approaches\/","title":{"rendered":"D\u00e9tection de l&#039;imp\u00e9tigo : diagnostic diff\u00e9rentiel, indices cliniques cl\u00e9s et approches th\u00e9rapeutiques fond\u00e9es sur des donn\u00e9es probantes"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Impetigo is a highly contagious infection in the epidermis or outer layers of the skin, primarily caused by\u00a0Staphylococci bacteria. The diagnosis is clinical, but it\u2019s critical to consider the patient history, your findings during a physical exam, and lab tests where necessary.<\/span><\/p>\n<h2><b>Impetigo in Patients<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">There are two forms of impetigo, known as nonbullous and bullous impetigo respectively.\u00a0<\/span><a href=\"https:\/\/www.crns.ca\/wp-content\/uploads\/2022\/02\/Impetigo-Adult-and-Pediatric-CDT-2022.pdf\"><span style=\"font-weight: 400;\">Nonbullous impetigo<\/span><\/a><span style=\"font-weight: 400;\"> is the most common form, characterized by rupturing blisters.\u00a0<\/span><i><span style=\"font-weight: 400;\">S. aureus<\/span><\/i><span style=\"font-weight: 400;\"> is the primary cause, especially in the early stages, but Streptococci bacteria tend to dominate in the later stages.\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-154699\" src=\"https:\/\/www.mdbriefcase.com\/wp-content\/uploads\/2025\/04\/Nonbullous-Impetigo-scaled.jpg\" alt=\"\" width=\"479\" height=\"298\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Bullous impetigo, on the other hand, is\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430974\/\"><span style=\"font-weight: 400;\">caused solely by\u00a0S. aureus<\/span><\/a><span style=\"font-weight: 400;\"> and is most prevalent in infants and children<\/span><i><span style=\"font-weight: 400;\">.<\/span><\/i><span style=\"font-weight: 400;\"> The bullae, or large fluid-filled blisters, appear as bacteria release toxins. Untreated or unresponsive bullous impetigo may develop into a deep ulcerated infection known as ecthyma.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-154697\" src=\"https:\/\/www.mdbriefcase.com\/wp-content\/uploads\/2025\/04\/Bullous-Impetigo-scaled.jpg\" alt=\"\" width=\"491\" height=\"327\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Some children or adults with pre-existing skin conditions, such as atopic dermatitis, may be more prone to infections.\u00a0Both forms often appear after a small break in the skin.<\/span><\/p>\n<h2><b>Key Clinical Clues of Impetigo<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Impetigo may be easily mistaken for other diseases, but a few\u00a0<\/span><a href=\"https:\/\/www.crns.ca\/wp-content\/uploads\/2022\/02\/Impetigo-Adult-and-Pediatric-CDT-2022.pdf\"><span style=\"font-weight: 400;\">signs and symptoms<\/span><\/a><span style=\"font-weight: 400;\"> can help you identify the condition. Patients may describe a painless itchy rash with red spots progressing to fluid-filled blisters. You may also see:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vesicles and pustules on the face, scalp, and hands<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Warm, red skin around the rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thick, golden yellow crusted lesion over a red rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Enlarged and tender lymph nodes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mild fever<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The golden-yellow crust is the tell-tale sign of impetigo. It appears as the blisters rupture and leak yellow pus that dries.<\/span><\/p>\n<h2><b>Differential Diagnosis\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Impetigo may mimic some conditions. Consider the following in your\u00a0differential diagnosis:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nonbullous impetigo<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Herpes simplex<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.canadianskin.ca\/pemphigoid-and-pemphigus\"><span style=\"font-weight: 400;\">Pemphigus foliaceus<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Candidiasis (yeast infection)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Scabies<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.mdbriefcase.com\/fr\/course\/best-practices-for-catching-up-on-herpes-zoster-hz-vaccination-in-the-pharmacy-cccep\/?courseid=1057\"><span style=\"font-weight: 400;\">Shingles<\/span><\/a><span style=\"font-weight: 400;\"> with blisters or crusts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Tinea corporis \u00a0(ringworm)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Varicella (chickenpox)<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bullous impetigo<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.canadianskin.ca\/pemphigoid-and-pemphigus\"><span style=\"font-weight: 400;\">Pemphigus vulgaris<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.canadianskin.ca\/pemphigoid-and-pemphigus\"><span style=\"font-weight: 400;\">Bullous pemphigoid<\/span><\/a><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Thermal burn<\/span><\/li>\n<li aria-level=\"1\"><a href=\"https:\/\/www.sjscanada.org\/what-is-sjs\"><span style=\"font-weight: 400;\">Stevens-Johnson syndrome<\/span><\/a><\/li>\n<li aria-level=\"1\"><a href=\"https:\/\/www.merckmanuals.com\/en-ca\/professional\/dermatologic-disorders\/hypersensitivity-and-reactive-skin-disorders\/erythema-multiforme\"><span style=\"font-weight: 400;\">Bullous erythema multiforme<\/span><\/a><\/li>\n<li aria-level=\"1\"><a href=\"https:\/\/www.gov.mb.ca\/health\/publichealth\/factsheets\/necro_fasciitis.pdf\"><span style=\"font-weight: 400;\">Necrotizing fasciitis<\/span><\/a><\/li>\n<\/ul>\n<h2><b>Evidence-Based Treatment for Impetigo<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Impetigo often clears with treatment within five days. However,\u00a0<\/span><a href=\"https:\/\/www.merckmanuals.com\/en-ca\/professional\/dermatologic-disorders\/bacterial-skin-infections\/impetigo-and-ecthyma\"><span style=\"font-weight: 400;\">early treatment<\/span><\/a><span style=\"font-weight: 400;\"> is essential to prevent scarring, cellulitis, or hyper- or hypopigmentation.\u00a0<\/span><\/p>\n<h3><b>Topical and Oral Antibiotics<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Antibiotics are the primary treatment for impetigo. You can prescribe topical or oral antibiotics, though a topical form is as effective for mild or moderate impetigo with fewer side effects. Effective\u00a0<\/span><a href=\"https:\/\/www.crns.ca\/wp-content\/uploads\/2022\/02\/Impetigo-Adult-and-Pediatric-CDT-2022.pdf\"><span style=\"font-weight: 400;\">topical antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mupirocin cream<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fusidic acid cream<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">You may need to combine topical antibiotics with oral for widespread infections, systemic symptoms, or family clusters. Oral antibiotics should cover group A beta-hemolytic\u00a0Streptococcus and\u00a0S. aureus.<\/span><i><span style=\"font-weight: 400;\">\u00a0<\/span><\/i><span style=\"font-weight: 400;\">Effective\u00a0<\/span><a href=\"https:\/\/www.crns.ca\/wp-content\/uploads\/2022\/02\/Impetigo-Adult-and-Pediatric-CDT-2022.pdf\"><span style=\"font-weight: 400;\">oral medications<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cephalexin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cloxacillin\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If your patient has a penicillin allergy, consider the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Azithromycin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clindamycin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sulfamethoxazole trimethoprim<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Doxycycline\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If your community has known cases of MRSA or the rash doesn\u2019t respond to treatment, take a swab to test for culture and sensitivity. Prescribe the oral antibiotics listed above for penicillin allergies with mupirocin cream, Polysporin triple therapy, or ozenoxacin 1% cream.\u00a0<\/span><\/p>\n<h3><b>Hygiene\u00a0<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Impetigo is highly contagious and spreads through direct contact with the rash or contaminated personal items such as linens, towels, and facecloths. Encourage\u00a0frequent handwashing with soap and water, and instruct patients to avoid touching their faces or sharing personal items.\u00a0<\/span><\/p>\n<h2><b>Learn More With MDBriefCase<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Impetigo is a common and often recurring infection. MDBriefCase offers many online and accredited courses on infectious diseases and other conditions to help you stay current on new evidence and best practices.\u00a0<\/span><a href=\"https:\/\/www.mdbriefcase.com\/fr\/user-account\/?action=eb_register\"><span style=\"font-weight: 400;\">Join for free<\/span><\/a><span style=\"font-weight: 400;\"> today.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Impetigo is a highly contagious infection in the epidermis or outer layers of the skin, primarily caused by\u00a0Staphylococci bacteria. The diagnosis is clinical, but it\u2019s critical to consider the patient history, your findings during a physical exam, and lab tests where necessary. Impetigo in Patients There are two forms of impetigo, known as nonbullous and [&hellip;]<\/p>\n","protected":false},"featured_media":2491,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"categories":[1],"class_list":["post-2488","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Spotting Impetigo: Differential Diagnosis, Key Clinical Clues, and Evidence-Based Treatment Approaches - MDBriefCase<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mdbriefcase.com\/fr\/blog\/spotting-impetigo-differential-diagnosis-key-clinical-clues-and-evidence-based-treatment-approaches\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Spotting Impetigo: Differential Diagnosis, Key Clinical Clues, and Evidence-Based Treatment Approaches - MDBriefCase\" \/>\n<meta property=\"og:description\" content=\"Impetigo is a highly contagious infection in the epidermis or outer layers of the skin, primarily caused by\u00a0Staphylococci bacteria. 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