{"id":2443,"date":"2023-03-28T00:00:00","date_gmt":"2023-03-28T05:00:00","guid":{"rendered":"https:\/\/mdbc2.wpenginepowered.com\/blog\/understanding-swallowing-difficulty-eosinophilic-esophagitis\/"},"modified":"2023-03-28T00:00:00","modified_gmt":"2023-03-28T05:00:00","slug":"understanding-swallowing-difficulty-eosinophilic-esophagitis","status":"publish","type":"blog","link":"https:\/\/www.mdbriefcase.com\/fr\/blog\/understanding-swallowing-difficulty-eosinophilic-esophagitis\/","title":{"rendered":"Understanding Swallowing Difficulty: Eosinophilic Esophagitis"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Dysphagia or swallowing difficulties can make it challenging to ingest food or beverages. Dysphagia can occur due to health conditions, including stroke,\u00a0<\/span><a href=\"https:\/\/www.mdbriefcase.com\/fr\/blog\/common-symptoms-and-treatments-for-multiple-sclerosis\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">multiple sclerosis<\/span><\/a><span style=\"font-weight: 400;\">, mouth or throat cancer, and gastroesophageal reflux disease (GERD). Inflammatory conditions like eosinophilic esophagitis can also cause it.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Eosinophilic esophagitis (EoE) is a chronic immune disorder that causes inflammation in the esophagus \u2014 the tube that carries food from the mouth to the stomach. It can occur when white blood cells or immune cells called eosinophils react to food, allergens, or acid reflux (backflow of stomach acid) in the esophagus. Eosinophils multiply and accumulate in the esophageal lining in response to foreign particles. This causes the esophagus to become inflamed and constricted, leading to swallowing difficulties.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Eosinophilic esophagitis\u00a0<\/span><a href=\"https:\/\/aacijournal.biomedcentral.com\/articles\/10.1186\/s13223-018-0287-0\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">prevalence<\/span><\/a><span style=\"font-weight: 400;\"> has increased over the past 20 years. Approximately five to 10\u00a0<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471489222000029\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">new cases<\/span><\/a><span style=\"font-weight: 400;\"> of eosinophilic esophagitis per 100,000 people emerge every year. In Canada, EoE impacts about\u00a0<\/span><a href=\"https:\/\/cdhf.ca\/en\/digestive-conditions\/eosinophilic-esophagitis\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">15,000 people<\/span><\/a><span style=\"font-weight: 400;\">. It is more common in adults than children and affects men more than women.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In Australia, the prevalence of eosinophilic esophagitis was reported to be 1 in\u00a0<\/span><a href=\"https:\/\/www.racgp.org.au\/afp\/2015\/october\/eosinophilic-oesophagitis-a-guide-for-primary-care#:~:text=The%20prevalence%20of%20EoE%20in,and%201%20in%2010%2C000%20children.&amp;text=Its%20prevalence%20appears%20to%20be,for%20by%20improved%20awareness%20alone.&amp;text=The%20hygiene%20hypothesis%20has%20been%20suggested%20as%20a%20cause.\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">100 adults<\/span><\/a><span style=\"font-weight: 400;\"> and 1 in 10,000 children in 2014. With no current data available,\u00a0<\/span><a href=\"https:\/\/insightplus.mja.com.au\/2022\/15\/eosinophilic-oesophagitis-a-tough-concept-to-swallow\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">anecdotal reports<\/span><\/a><span style=\"font-weight: 400;\"> from local gastroenterology experts suggest that the incidence of eosinophilic esophagitis is increasing across Australia.\u00a0<\/span><\/p>\n<h2><b>What Are the Signs and Symptoms of Eosinophilic Esophagitis?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The primary symptom of eosinophilic esophagitis is inflammation in the esophagus. Other signs and symptoms in adults include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swallowing difficulties<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Impaction or food getting stuck in the esophagus on swallowing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pain in the center of the chest that does not resolve after taking antacids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Regurgitation of backflow of undigested food<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Children with eosinophilic esophagitis have similar symptoms. They additionally have difficulty feeding or eating, abdominal pain, and vomiting. EoE in children can lead to poor growth,\u00a0<\/span><a href=\"https:\/\/www.mdbriefcase.com\/fr\/blog\/how-to-reduce-the-impact-of-malnutrition-in-your-patients\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">malnutrition<\/span><\/a><span style=\"font-weight: 400;\">, weight loss, and failure to thrive.<\/span><\/p>\n<h2><b>How Is Eosinophilic Esophagitis Diagnosed?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">If a patient shows symptoms of eosinophilic esophagitis, the following tests are recommended to diagnose the condition:\u00a0<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Upper gastrointestinal endoscopy.\u00a0<\/b><span style=\"font-weight: 400;\">This gastroenterology test examines the esophagus from the inside. It uses an endoscope \u2014 a long, narrow tube with a light and tiny camera \u2014\u00a0inserted into the esophagus through the mouth to inspect the esophageal lining for swelling or narrowing.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Biopsy.\u00a0<\/b><span style=\"font-weight: 400;\">During endoscopy, you can biopsy the esophagus, removing a small tissue sample, and examine it under a microscope to detect eosinophils.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Esophageal sponge or cytosponge.\u00a0<\/b><span style=\"font-weight: 400;\">The test involves swallowing a capsule with a string attached. Once your patient swallows the capsule, it dissolves in the stomach and releases a sponge called a\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9991209\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">cytosponge<\/span><\/a><span style=\"font-weight: 400;\">. Pull the sponge out of their mouth using the string to collect the esophageal tissue sample. This test acts as a substitute for endoscopy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Blood tests.\u00a0<\/b><span style=\"font-weight: 400;\">You can recommend additional blood tests for your patients to confirm the diagnosis. These can include testing for allergens or allergy-causing substances in the body, eosinophil counts, or antibody levels.<\/span><\/li>\n<\/ol>\n<h2><b>What Does Eosinophilic Esophagitis Treatment Involve?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Eosinophilic esophagitis is a chronic illness that can relapse if patients are not careful. It requires ongoing treatment to manage the symptoms. Eosinophilic esophagitis treatment involves the following:<\/span><\/p>\n<h3><b>Diet Therapy<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If your patient is diagnosed with eosinophilic esophagitis due to a food allergy, ask them to stop eating the particular food. Avoiding common allergenic foods such as gluten and dairy may reduce inflammation and other eosinophilic esophagitis symptoms.\u00a0<\/span><\/p>\n<h3><b>Medication<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">You can prescribe the following medications to ease the symptoms:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Proton pump inhibitors\u00a0<\/b><span style=\"font-weight: 400;\">such as omeprazole or pantoprazole reduce stomach acid production.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Topical steroids<\/b><span style=\"font-weight: 400;\"> such as fluticasone or budesonide reduce inflammation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monoclonal antibodies\u00a0<\/b><span style=\"font-weight: 400;\">such as\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6110636\/#:~:text=Dupilumab%20is%20an%20interleukin%2D4,and%20IL%2D13%20receptor%20complexes.\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">dupilumab<\/span><\/a><span style=\"font-weight: 400;\"> reduce inflammation and allergic responses.<\/span><\/li>\n<\/ul>\n<h3><b>Esophageal Dilation<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">You can use dilation if a patient&#8217;s esophagus is severely constricted or narrowed. Dilating or stretching the esophagus makes swallowing easier and helps avoid continuous medication.\u00a0<\/span><\/p>\n<h3><b>Lifestyle Changes<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If your patient frequently experiences acid reflux or heartburn, you can suggest\u00a0<\/span><a href=\"https:\/\/aboutgerd.org\/treatment\/diet-lifestyle-changes\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">lifestyle changes<\/span><\/a><span style=\"font-weight: 400;\"> to help reduce its frequency. Ask them to avoid foods or drinks that trigger heartburn and to maintain a healthy weight. Also, keeping their head elevated while sleeping can prevent acid reflux. \u00a0\u00a0<\/span><\/p>\n<h2><b>What Are the Current Findings on Eosinophilic Esophagitis?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Researchers are currently studying potential therapies to treat eosinophilic esophagitis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some studies show that monoclonal antibodies like\u00a0<\/span><a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(20)30348-7\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">RPC4046<\/span><\/a><span style=\"font-weight: 400;\"> and\u00a0<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471489222000029\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">reslizumab<\/span><\/a><span style=\"font-weight: 400;\"> help manage eosinophilic esophagitis symptoms. Researchers have found a new monoclonal antibody called AK002 that targets specific\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6556424\/\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">receptor molecules<\/span><\/a><span style=\"font-weight: 400;\"> on eosinophils and improves symptoms of dysphagia. Another new antibody called\u00a0<\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19420862.2017.1332553\" target=\"_blank\" rel=\"nofollow noopener\"><span style=\"font-weight: 400;\">CALY-002<\/span><\/a><span style=\"font-weight: 400;\"> can reduce the levels of pro-inflammatory molecules like interleukin 15, which may relieve eosinophilic esophagitis symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, experts are studying the accuracy and efficiency of diagnostic techniques such as the cytosponge to detect eosinophilic esophagitis without endoscopy.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With further research underway, novel diagnostic tools and targeted therapies can help detect the condition early and resolve symptoms without requiring continuous treatment.\u00a0<\/span><\/p>\n<h2><b>Learn More With MDBriefCase<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Enroll in the course on eosinophilic esophagitis and swallowing difficulties by<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/www.mdbriefcase.com\/fr\/course\/swallowing-difficulties-and-eosinophilic-oesophagitis-eoe\/?utm_source=webpage&amp;utm_medium=blog&amp;utm_campaign=awareness\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">MDBriefCase<\/span><\/a><span style=\"font-weight: 400;\"> to improve your awareness and manage and support your patients better.\u00a0<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Dysphagia or swallowing difficulties can make it challenging to ingest food or beverages. Dysphagia can occur due to health conditions, including stroke,\u00a0multiple sclerosis, mouth or throat cancer, and gastroesophageal reflux disease (GERD). Inflammatory conditions like eosinophilic esophagitis can also cause it. Eosinophilic esophagitis (EoE) is a chronic immune disorder that causes inflammation in the esophagus [&hellip;]<\/p>\n","protected":false},"featured_media":2444,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"categories":[64],"class_list":["post-2443","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-deep-understandingfurther-educationlearning-and-development"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Understanding Swallowing Difficulty: Eosinophilic Esophagitis - MDBriefCase<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mdbriefcase.com\/fr\/blog\/understanding-swallowing-difficulty-eosinophilic-esophagitis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding Swallowing Difficulty: Eosinophilic Esophagitis - MDBriefCase\" \/>\n<meta property=\"og:description\" content=\"Dysphagia or swallowing difficulties can make it challenging to ingest food or beverages. Dysphagia can occur due to health conditions, including stroke,\u00a0multiple sclerosis, mouth or throat cancer, and gastroesophageal reflux disease (GERD). Inflammatory conditions like eosinophilic esophagitis can also cause it. 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